Skeletal Muscle Engineering and Regeneration
Our research utilizes advanced microfluidic-assisted biofabrication techniques to create highly functional and organized muscle tissues. By integrating in-house built microfluidic extruders, we are aiming to enhance precision in biomimetic architecture of natural skeletal muscle tissue.
Our ultimate goal is to unravel the complexities of skeletal muscle plasticity and to develop cutting-edge solutions for muscle regeneration and modeling in vitro human biology.
Key Research Areas:
Microfluidic-Assisted Biofabrication and Muscle Plasticity: By combining microfluidic-assisted biofabrication with high-throughput proteomics, we are aiming to explore the adaptive responses of skeletal muscle under active physical stimulation. We aspire to deepen our understanding of muscle plasticity and optimize engineered muscle tissue design that can closely mimic native muscle functionality.
AI-Driven Bioprinting and Human Biology Modeling: We are currently discovering the integration of artificial intelligence tools with microfluidic-assisted bioprinting. Our goal is to create a comprehensive understanding of modeling in vitro skeletal muscle models which will enhance our ability to accurately replicate and study complex biological processes.
Electromechanical Stimulation in Muscle Development: Our team investigates the role of electromechanical stimulation in muscle development, focusing on how these stimuli can influence forming muscle fiber types-fast/slow twitching-, maturation, and functional capacity. This research is key to enhancing the performance and applicability of engineered muscle tissues for therapeutic use.
Designing and Vascularizing Engineered Muscle Constructs: We are advancing techniques to pre-condition volumetric engineered muscles for rapid vascularization, ensuring their survival and functionality upon implantation. Our work aims to develop vascularized muscle constructs that can seamlessly integrate with the host's circulatory system, supporting long-term regeneration and function.